The only big game animal I've shot with my 22-250 was an antelope last year. Mine is also a 1-14". I used a 55 gr Sierra STB Gameking. It was a close shot, under 100 yds. I hit it just behind the point of the elbow. I found the bullet in the far shoulder looking like I'd dropped it in a blender. Between the entry and exit points was a pool of mush. It obliterated the heart and lungs.
Antelope aren't very big. For a large deer, I would prefer some more weight, like Sierra's 63 gr GameKing. I won't use this rifle for deer hunting, though, because it weighs a lb more than my 30-06.
