Three years ago, I shot a bull moose on the point of his shoulder at 55yds. The 250 Accubond had a muzzle velocity of 3,000 ft/sec. At the shot, the big bull reared up and flipped over backwards. His palms slammed into the ground and he never moved again. The bullet traveled through both shoulders and was caught in the off-side skin. IIRC the expanded bullet weighed in at 140gr.
Quite remarkable performance.
Interestingly enough, I am hunting moose in Newfoundland again this week. I decided to not mess with a good thing and I'm using the same gun and load. The fact that it shoots .5moa at 400yds doesn't hurt either.