I've had that 200 grain Spire Point come apart on whitetail bucks when started 100fps slower than your .350 RM and no longer trust them for hunting. I've killed 9+ brown bear using 200 TTSXs at similar velocity and would do so again without reservation. I've found cup & core bullets need more mass to reliably penetrate when used at /350 RM velocity levels. I'd use 250 Hornady or Speer SP for black bears without concern. 225 & 250 grain NPTs are fine, but not at all necessary in my experience.
