IMO - With any 243, 6.5, 7 mm, 30 caliber cartridge it becomes a question of how much powder do you want to burn and how much recoil do you want to endure. Choose any of them in a chambering you like with a recoil level that you can comfortably handle and go with it.
In my experience the less the recoil the better one can shoot.

drover

223 Rem, my favorite cartridge - you can't argue with truckloads of dead PD's and gophers.

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