#2 cause is poor bullet performance.
For 8 or 10 years I used 180 gr AB's in a 300 WSM. I had some problems like bullet separation. In one case, I hit the shoulder but not the bone and the bullet came apart. The shoulder was obliterated. I found the copper in the shoulder and later found the core in the heart. I was less than impressed.
I've been assured that Nosler has fixed the problem so, to give them a fair chance, I used them again this year in a 30-06. However, I didn't get a chance to shoot anything with them so I can't comment on performance. I can say that they're highly accurate.