Automatics of any flavor are likely a no-go for her. Maybe a weak-springed .380, but nothing larger.
Frankly, in helping a few elderly folks select handguns (including my own mother), I have found that larger framed guns, not smaller guns fit and feel better. My mom couldn't operate any automatic effectively and ended up with a Ruger GP 100 .357 Magnum. She shoots .38's out of it pretty comfortably.
If your lady has trouble with recoil, then suggest a Simth 48 .22 WMR. The cartridge is not a great choice for home defense, but at least you're following Rule #1 for being in a gunfight (Bring a gun).
Good luck!
