I've got a pair of 250s, along with my 257 Roberts they are my favorite deer rifles.
A 1953 built(same as me)M99R Savage. The slow twist hampers it a little, but the short Speer Hot Core 100gr spitzer works well enough. I've worked up loads with the Speer Hot Core 87 gr spitzer and the TNT 87hp that share the same sight setting, so that's what it stays sighted at. I've taken several whitetails with it and had no surprises.

A Ruger M77 Tang Safety 250-3000 is slightly more accurate and shoots a wider array of bullet weights with the 1-10 twist. This one does very well with 75 Sierra hps or 87 Speer TNT. So far I've found nothing in the 100 gr category that does better than the Hornady Interlock. On game or paper, it just works.

This mature 161" buck last year found out just how well it works, stumbled less than 30 yards after a quartering to shoulder shot at 150 yards.
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