I have settled on a load for my .454 Casull, using 32.5 gr. of 4227 powder, and Hornady's excellent 240 gr. XTP Mag. bullet. MV is around 1500 fps out of my 10" barrel. Used this load last fall on wild hog and red deer, with great results and pass-through performance. I no longer shoot full-power stuff out of my Casull- reducing factory ammo MV's by 300-400 fps makes a huge difference in recoil, and as far as I can tell, no effect on killing efficiency.
If I were going after really big stuff, like bison, for example, then a heavy cast bullet or the Hornady 300 gr. XTP Mag, or some of the original FA JFP bullets I still have around, might be the better choice.
