I shot my first elk with a 243 win with 100 gr Winchester power points, it worked just fine. I wouldn't go elk hunting with a 243, but if I had one in my hand when a shot presented itself I wouldn't hesitate. I would make sure I had a good shot. A couple years ago I killed a cow with a 6.5 140gr partition out of a 256 Newton. The velocity was so close to what I get with the same bullet in my 6.5 CM that the difference in negligible. At the shot the elk ran about 50 yards and stopped where I hit her again. It worked great, but I remember thinking that the results of shooting elk with a 200gr 30 cal partition were a little more dramatic. Bottom line is put a good bullet in the heart/lungs and start looking for the easiest route back to the truck. cool