The minimum cartridge I would be comfortable with?. A 6,5 Creed or similar using a 130 grain quality bullet at 2700 fps or more. A .300 Savage 150 grain would be fine with me as well.

The two I use the most?. A .30-06 with 180NPT's or a .338 Win Mag with 225 TBBC's has been my choice for several years. Before that it was a .308 Win.

That said, three of my female relatives have been using .243's and 6mm Remingtons for well over 25 years with reliable results.