Any road leading out of Indiana.
Really? While I've no use for Indy or Fort Wayne, I found the Columbus area to be not all that bad. Politics that horrible in IN ?
As for drives, there are some I won't mention on the interweb. Too much fun as they are, no need for more traffic.
Some that haven't been mentioned, or mentioned improperly
CA 1 from San Simeon to Carmel. AKA Big Sur
US 50 from Fallon NV to Salina UT
CA 35 from CA 92 down to CA 17
Absolute worst: US 5 through the Central Valley with holiday traffic. I'd rather be stuck in stop-n-go on 80 trying to get over the Bay Bridge...
