Mine's parked at 35.3 grain of Re7. Seems to do okay. Like I said, I can't see my sights well at all, but I managed to keep five shots well under 2 inches at 50 yards. My guess is it shoots every bit as well as I can aim it. I'm getting about 2075 fps out of it according to my spreadsheets. I mis-remembered that 2250 fps business.
I looked up what Ken waters had to say about the Speer 235 expanding at .375W velocities---just last night in fact and I already don't recall exactly what he said about it, but it amounted to something like "I ain't too sure."