I agree with those lads shooting Western Ground squirrels who are not very large. It seems like all ammo works on them if hit in the body but HP's are more sudden and acrobatic.
I like shooting them with the ammo that works best in that rifle.

However when shooting jackrabbits, who are big and can be tough, it's HP's all the way and lately it's been a .17HMR. Ground squirrels are usually taken at closer range for me like the 25-60 yard range while the jackrabbits, if stationery, are from 50-100+ yards. Hitting a jackrabbit with a .22lr at 125 yards is usually a test but with the .17 HMR,.....it's cake.