Last year I did most of my coyote hunting with a 22-250 using 40 grain VMax's as fast I could push them. Every coyote was DRT, no exits, no runners. Coyotes aren't to kill, so a wide variety of bullets work.

My only problems came with the 204 and the 32 grain VMax. Had several cases of bullet splash and no penetration. 35 grain Bergers fixed that little problem.