My sample of one charging brown bear died from 300 Wby & 180 gr. Barnes-X (pre-TSX). First shot rolled her down a small hill at about ~ 5 yds (or less). She was up and running away and my second shot at 50-ish yards put her down.
Bob Enjoy life now -- it has an expiration date. ~Molɔ̀ːn Labé Skýla~