I'm no expert and only have limited experience but I have shot both interior grizzly and brown bears with both the 30 cal 200 Nosler Partitions and .375 cal 270 TSX. Either will do exactly what they were designed to do IF properly placed. If I had to decide today i would go with the Barnes TSX in 180- 200 grain in 30 cal or 270-300 grains out of a 375. YMMV
