Hunting camp chat, after a few whiskey.
These new mono's change the picture quite alot. The 6.5 's with a good copper bullet is adequate, 500 yards too is far , imo, for any chambering.
Believe it or not we have killed elk with a 22/250- not recommended.
Our southern moose are easier to kill than elk, imo.
A mature bull will take a vital shot and run, you had best follow. The old guy might be piled up in the creek bottem.