I shoot 325 grain cast with gas checks out of my Marlin 45-70.
Shot some 300 grain jacketed hollow points after loading up some for a friend.
Longest shot was a hog at 165 or so yards and he did not like it at all.
My friend has shot quit a few mule deer at somewhat longer ranges.
As said hold on good if full house loads are shot,it will make a nice cut over the eye or get the bridge of the nose in a hurry.
