I've used the 30-06 with the old Hornady Light Magnum 180sp on a running cow at 135 steps. Broke her spine behind her shoulders. I popped her high lung as she was trying to get up. Since I was planning a S.A. PG hunt later, I used a 375 H&h/300 Sierra ( bullet too soft) and later on a 338WM(185 Barnes) I have a hunting buddy who uses nothing but the 308/150 corlokt on them! Both the 30.06 & .308 are quite effective. BTW, my average on 3 cows is 190yds.