I just bought a 650 and set it up from scratch for 45. No issues and pretty easy if you are at all mechanical. If you get the 650 (now the 750) you 100% want to get the case feed. With no case feed, you might as well get a 550. Something to think about....45 brass now comes in both large and small primer. If you order ammo for the brass, make sure you get the primer size of your choosing. Also, it is a pain to change primer sizes on the 660. If you plan on loading other small primers cartridges (.38/.357, 9, 5.56) on the Dillon, it may be easier to just use small primer .45 brass. I have tons of LP stuff, but I have considered selling it and buying SP brass. The good thing is, SP brass is cheaper. I may just buy another machine for SP cartridges. Bottom line, you can’t go wrong with any Dillon. One last thing, if all you care about is .45, a SDB is supposed to be a nice and inexpensive ‘set and forget’ press for a one caliber loader.