I have used both the Barnes TTSX 250 gr. and the TSX 270 gr. in .375 on large game, with equally satisfactory results.
Are you planning to go with an outfitter? If so, you need to inquire as to their preferences for shot placement. If head shots are recommended, it really doesn't matter much what you use, as long as the bullet will penetrate the skull.
Just last week I took a meat bison with my .480 Ruger, and the outfitter I hunted with recommended a head shot, for several reasons, including the fact that we were hunting in broken terrain where a bison hit and ran off would be a large problem, if it died in a deep ravine.
