I took my first bull with a Rem 700 Mountain rifle in .280 with 140 or 160 TBBC. Never found it lacking and took two more with it.
My daughter also used it to take her first elk, a 6x6 in NM.

Bought a Montana 300 WSM when they first came out and between my son in law and myself its accounted for 17 elk.
All with 165 TSX factory load. My SIL uses it now.

I now hunt with a Ultra Light Arms 300 Win with 165 Barnes TTXS that belonged to a hunting buddy. He gave it to me the day before he passed.

All are light enough to carry easily in the mountains, shoot tough bullets that break bones and penetrate on quartering shots, and can easily shoot to my limit of 4-500 yards.