My preference is for .308 caliber over a 6.5 for elk and bear. But no doubt the 6.5 will work if the bullets are put in the right place. I think these things are mostly about personal preference. If it were me, I would pick a 30-06 but a .308 would also work well. Pretty had to beat either of those cartridges for a wide variety of uses, especially for game larger/tougher than deer.