I loaded the Hornady 180 Interlock in various 300 WIN MAG rifles for decades. Used Alliant Re22 and never had a bullet "blow-up" or lost a deer. I'm using those bullets up in a 30-06 SPRG now, been using a Mule Deer load using Hunter powder, the bullets still perform fine on whitetail. I use the 165 Interlock in my 308 WIN, get the same grade of performance.