64 grain power-point has worked well for me on Texas deer in a .223. I don’t know if the additional velocity in a 22-250 would have a negative effect on the bullet at close range.
I worked up a load with 64 gr power points(these were designed with 223 wsm velocities in mind) for my 22-250 at 3400 fps. Shot 3 antelope 1 shot a piece , all drt. On 1 doe I put the crosshairs on purpose right on the ball and socket joint of the left shoulder to see if I would get full penetration with exit at 175 yds it did. 22 bullets aren't all created equal good luck. Mb
