I just tested some Speer 75 gr Gold Dots in a 1/8 twist Tikka .22-250. With RL-16, they were shooting knots and were coming out b/t 3,125 and 3,242 fps dependent on charge weights. I think they would make excellent deer medicine.
I've gotten the 75 Gold Dots to just over 3000 fps out of a 22" 1:8 223 loaded with 450's and CFE223. I'm sure they will be quite excellent killers, given how well the 62s and 64s of the same design have worked for me on deer at your 75 gr 22-250 velocity in my 223.
