33 Years in Alaska and I mostly used a 338 Win Mag. Handled everything I needed, and was very pleased with it. Rugers Stainless rifles is good steel. Only exceptions is I shot a big moose and a grizzly in Haines with my 375 H&H, and some Caribou up on the slope with my 30-06 out of Barrow. If I was a one rifle guy it would be a 338WM, and I'm totally sold on the 250 NP. That's all I used.
IB I don't see you being to old to use a 338 WM. Might be the right caliber for you.