Factory grips on the HP are terrible; and yet it still feels fantastic in your hands.

So if you were to take the same make of grips (pick VZ for instance) and put them on both guns, I think you'll find both guns to be very ergonomic. The CZ has a larger grip circumference, and a longer reach to the trigger in DA mode. I think people with smaller hands would appreciate the HP more, and people with larger hands would absolutely love the feel of a CZ75.