Your response to an assailant would depend on the weapon they have.
A knife is the most practical for a defense to empty hand attack against you, but.......I was attacked with an axe..........so I grabbed what was handy and that was a shovel......I won........they went to the hospital and I went home.

Having a fundamental understanding of the "angles of evasion" and the clever use of your hands are where its at.
Knife.
Hands.