I would strongly recommend looking at the regulations for each state you will need to pass through. The CWD-related regulations have been changing frequently, and sometimes annually. Worse, some have been changing even during the season.
A couple years ago my NY nephew came out to hunt WY. He found out while he was here that NY state CWD regulations had changed after he left there. The WY season opened prior to the NY opener, and NY wanted to have new regs in before the NY season opened. Therefore, just before he was to go home with a head, we had to scramble to meet the new regulations. His head had to be fully cleaned of all brain and flesh. Pretty much all states now are requiring only boned meat cross state lines.
In WY, most recently, if an animal is killed in a CWD unit, you pretty much need to bone it at the kill area and leave skeletal material where it was killed, so you are not even supposed to transport skeletal parts inside the state from a CWD area.
Each state is a bit different. Some states prohibit brain, spinal cord, bones leaving the state, others prohibit such parts entering the state. A few appear to only allow cleaned skullplates to travel - no full skulls for Euro mounts. It is best to do the homework and plan accordingly.
Also echo the recommendation that if you get something big enough you can't get it inside the vehicle that you never leave it out where it can be stolen, especially overnight, because that could be very likely in some places. Would certainly take the shine off a hunt. Seems like you should be able to make them fit, but as someone else noted, soft duffels and smaller containers will probably make packing stuff around them easier. You could also consider shipping some gear home once you don't need it.
