A guy I know slightly once shot his African PH in the back as they were hunting Cape buffalo. Luckily the guy was using solids in a .458 Winchester, which of course made a lot smaller hole than an expanding bullet, and the client survived.
The rifle was a Model 70 Winchester with its vaunted 3-position safety, which once again suggests that the most important firearm "safety" is not located on the gun, but between the hunter's ears.
