Holy big gun batman. A 460 for deer? The uber truthful internet has stories of people taking deer with everything from a .22 on up, 9mm, 40sw, and 45acp. I'm sure a 40/45 would be adequate within 30 yards or so, but I think they are a little light. For me a 357, 10mm, 41mag, 44mag, 45 colt would be where I'd focus my attention. Something with a 3-6 barrel. (A 3" barrel on a revolver is about the same as a 4.5-5" barrel on a semiautomatic). It's handgun hunting not small rifle hunting. If you put a red dot or scope on it, barrel length doesn't matter in terms of accuracy from a longer sight radius.