I will breakout a handgun for WT every few seasons or so to mix things up. I have used a 6” .357, Glock 40 MOS 10mm, 6” .44mag, and .45 ACP.

The 10mm is fun and with the red dot is effective. The .44 is the overall winner. None have been super impressive as far as performance but I like the larger hole the .44 puts through a deer.

A true big-bore cartridge is on my wishlist but if you want an auto, the 10mm works. If you want a moderate wheel gun, a .44 or .45LC will work fine. I have no experience with the .41 but a friend does and likes it but it has to be similar to the 10mm. The .357 worked for me on a nice FL buck I grunted up to 20 yards but it was a very lackluster experience and worked but I would not intentionally choose to do it again. I have taken a few deer with a .45 ACP but were follow up shots while tracking so they were considered backup kills but none the less took deer.