I have shot moose with a bunch of different CF bullet/cartridge combinations from 270 with 130gr Speer to 375AI with 270gr X bullets, including two Whelen AIs and a regular Whelen. Years ago I settled on a 30-06 and light TTSXs. My first moose died from a 22LR behind the ear.
The last thing to worry about is the cartridge. The first thing is the bullet, closely followed by placement.