I've had good results with the 154's on deer. I have not tried it on elk. I would not be afraid to use them on elk and a 280 though.
It's been a while since I've used that combination, who knows, they may have changed the bullet construction.
That's it in a nutshell Hornady's admin beancounters on a regular basis have their engineers fu*k up proven designs to save a nickel on 10 dollars in production costs every damned time..mb