We shot two black bear a couple/three years ago with 165 flat base interlocks out of a 30-06, which resulted in two very dead bears with a total blood trail of maybe 10 yards. Bullets were relatively new manufacture, fwiw. I have been using 139 flat base (280) and 130 flat base (270) interlocks on several mule deer for the last decade or two, with very predictable results.