Originally Posted by TheKid
I’ve found through much experimentation that no animal can live with a 2” hole through its lungs. They don’t know or care what put the hole there. Many projectiles are available that will enable even a lowly .224 caliber rifle to put a 2” hole through a lot of tissue.

Pick a rifle. Select a decent bullet. Put it where it needs to go. Caliber and more so headstamp mean less than ever before with modern projectiles.
So true. Good example happened a few seasons ago. One deer was struck with 338 win mag, blew a literal fist size hole through him. Second was shot by 223 in the identical spot. Both ran 80 yards.