It should be noted that both QuickLoad and reloading manuals are only a guide. You should always work up you own loads. I no longer have access to a pressure transducer and other equipment to validate loads, so can't confirm the accuracy of QuickLoad other than velocity predictions, which tend to be pretty good.
Using the data QL generates, I have yet to see anything that looks dangerous. Most loads are on the low side when compared to loading manuals. But everything is fallible.