AD,
Let's face it: You WANT to to take the .270/.375 battery to Africa. By all means, do it. I've done the metric equivalent, the 6.5 X 55 Swede and the 9.3 X 62. It performed well. The 6.5 Swede handled everything right up to kudu without a hitch.
Part of the pleasure of being a gun nut is taking your obsessions to the field.
There is a certain romance to the classics, and that is about as classic as a combo could be. I think O'Connor was on to something good. Time to do it and tell us about it. Good hunting!