I've killed several animals with my 358 including three moose, one which the 358 was only an "assist" on. And I've used and liked the 225X as much or more than any others. That bullet, with AA2230, would move at over 2300 fps and seemed to hit with far greater effect than any 250 SP. AA2520 is a good powder when you want to kick a 250 along at 2300 fps from 20 inches of barrel, something I have found challenging with other powders.

Sometimes, the air you 'let in'matters less than the air you 'let out'.