Ruger,

I have shot a few head of deer sized game with the 250 K at 1,000-1,100 fps. and have never recovered one (no surprise).
A friend also uses the 250 LFN out of a 45 Colt for deer at under 1,000 fps. with complete penetration on broadside shots, decent damage and short trails.

The reason why so many use cast bullets is expense in shooting. Cast loads for handguns drive down the cost so you practice more and hit where you want to, which is pretty much all that matters unless your selling concepts.

The very best jacketed bullets are certainly works of art, but the cost is generally like buying rifle bullets: boxes of 50 for over 30 dollars. Hard to practice that much with those great bullets, then you realize the cheap loads you have become so accustomed to will do the same amount of killing without trying to get the bullet to open up with more speed or breaking the bank.

At handgun speeds, jacketed bullets are just not needed IMO.