I'm sure a 45-70 will kill at suprising ranges. If you are going to be taking shots past 200-250 yds. there are better choices IMHO.
One of the best Factory offerings in this caliber has a drop of -28" @ 300yds. and that is sighting the rifle in 3" high at 100 yds.
Anything further than that, you'll have an arc like a mortar round, making hits to the vitals alot more difficult to pull off.
It's a great rifle and caliber, but it ain't no long range rig.
That's just a fact.
JM