I use a starting load of IMR4895 for range practice, though you'll probably want to try several powders to see what your rifle likes. Very little brass wear with starting loads, and it shoots just fine - though a few inches lower than a hunting load. Load her up just like any other centerfire round, just be aware that long bullets like 180gr or above tend to eat up a lot of powder space in order to be kept short enough to fit in the magazine. They still work fine, it just seems weird when loading them. I tend to use Nosler BT's 2nds for practice, I hunt with Partitions and the BT's are pretty good about keeping very close to the same POI.

I don't use cast bullets, doesn't seem right in a 250 or 300 Savage.