When shooting under threat, whether human or animal, hold somewhat low. Natural instinct is to take too coarse a bead, holding up too much front sight, such that in relation to the front sight, the shots tend to go high.
As to the lead required on a running shot, it's moot, don't take it. Lots of line-of-sight rate/crossing shots are difficult under perfect circumstances, let alone under duress. As others here have said, not much need for such a shot in self defense. For the frontal shot, another matter altogether. Hold low, keep shooting.
You might also want to consider filing down the front sight...
