I like 120gr bullets (Speer, Hornady, Sierra have all worked well) with stiff loads of 4831 (either H or IMR). Velocities are 2900+ and deer die just like they were hit with a 270, 280, 264, 308, 7-08, ad nauseam).

This past deer season, just to see what the hype was all about, I tried 80gr TTSX's with 4064. That combo works well, too.