Yeah, pretty much. The .25-06 will has about a 3-4% advantage in velocity over the 6.5x55 with the same bullet weights, and the 6.5x55 offers a little heavier bullet weights. But having shot a few animals with both I doubt anybody's going to see much difference at ranges out to 500 yards. Beyond that the 6.5's have an advantage, but not at what most hunters consider "normal" hunting ranges.