Shot two Mulies out west[Eastern Sierra's] with 165 GMX's from my Ruger MkII .30-'06. Pretty much dead right after the shot, about 200-225 yards. One didn't move, other than tipping over, the other staggered maybe 10-15 yards, plop. I don't recall MV, as my notes are packed for moving, but thinking 2850-2875fps might be about right. Powder was/is Ramshot Hunter: 59.5gr.
Hope this helps.