I use my Nula 300 WM almost exclusively on deer, elk, and antelope. Why because I can place the shot on the hair I aim at. My 06 actually kicks harder than the 300, a credit to Melvin's stock and pad. I had the rifle made for me and just love the 300 WM as a all around cartridge. The 45/70 comes out once in a while but the 300 is first choice 99% of the time. I've killed Elk with all 3 rifles they didn't know the difference!!! If you can shoot it we'll use it. The key is shoot it and then shoot it again, against a tree, on your belly, squatting down standing up just shoot it.