From reading various gun articles it seems the .338 is a better long range round than the .375 H&H and carries more freight than the 7mm. However, when I first saw the .375 Ruger my 1st thought was this would make the .338 obsolete. Combine being able to fit in a 30-06 action with more power than the .375 H&H.

Saying that I have a .338 WM and a .375 H&H and have never handled a .375 Ruger so my thoughts are meaningless.