Really you have to ask yourself: "Am I a rifle looney or at least headed that way?" If the answer is yes then you are pretty much doomed into buying the 338. The mere fact that you are asking means you will always be wondering, so good luck with that. Another problem you face is that though you may be able to rationalize performance away ( maybe), the physical gaps between the .284 and .375 will always be there to pollute your mind.